ChloroquineV1, Main, Exploration, bibRecord, 002219

Idiopathic interstitial pneumonitis in children: A national survey in the United Kingdom and Ireland

Identifieur interne : 002219 ( Main/Exploration ); précédent : 002218; suivant : 002220

Idiopathic interstitial pneumonitis in children: A national survey in the United Kingdom and Ireland

Auteurs : R. Dinwiddie [Royaume-Uni] ; N. Sharief [Royaume-Uni] ; O. Crawford [Royaume-Uni]

Source :

Pediatric Pulmonology [ 8755-6863 ] ; 2002-07.

RBID : ISTEX:2F2A42A20CB2BEF20778D650B9EE95D65958F42F

Descripteurs français

KwdFr :
- Adolescent, Enfant, Enfant d'âge préscolaire, Enquêtes de santé, Femelle, Humains, Irlande (épidémiologie), Mâle, Nourrisson, Pneumopathies interstitielles (), Pneumopathies interstitielles (physiopathologie), Pneumopathies interstitielles (épidémiologie), Royaume-Uni (épidémiologie), Répartition par âge, Résultat thérapeutique.
MESH :
- physiopathologie : Pneumopathies interstitielles.
- épidémiologie : Irlande, Pneumopathies interstitielles, Royaume-Uni.
Pascal (Inist)
- Enfant, Forme clinique, Idiopathique, Pneumopathie interstitielle, Pronostic, Royaume Uni, Traitement.
MESH :
- Adolescent, Enfant, Enfant d'âge préscolaire, Enquêtes de santé, Femelle, Humains, Mâle, Nourrisson, Pneumopathies interstitielles, Répartition par âge, Résultat thérapeutique.
Wicri :
- topic : Enfant.

English descriptors

KwdEn :
- Adolescent, Age Distribution, Child, Child, Preschool, Clinical form, Female, Health Surveys, Humans, Idiopathic, Infant, Interstitial pneumonitis, Ireland (epidemiology), Lung Diseases, Interstitial (epidemiology), Lung Diseases, Interstitial (physiopathology), Lung Diseases, Interstitial (therapy), Male, Prognosis, Treatment, Treatment Outcome, United Kingdom, United Kingdom (epidemiology).
MESH :
- epidemiology : Ireland, Lung Diseases, Interstitial, United Kingdom.
- physiopathology : Lung Diseases, Interstitial.
- therapy : Lung Diseases, Interstitial.
Teeft :
- Adolescent, Age Distribution, Alveolitis, Biopsy, Bronchoalveolar lavage, Brosing alveolitis, Child, Child, Preschool, Clinical practice, Conventional treatment, Desquamative, Dinwiddie, Female, Fibrosing alveolitis, Good outcome, Grant sponsor, Great ormond street hospital, Health Surveys, Histological, Histological change, Humans, Hydroxychloroquine, Idiopathic, Individual data, Infant, Interstitial, Interstitial lung disease, Interstitial pneumonitis, Lung biopsy, Lung disease, Male, National survey, Natural history, Open lung biopsy, Orid desquamation, Other treatments, Oxygen saturation, Partial response, Pediatr, Pediatr pulmonol, Pediatric pulmonology, Pneumonitis, Recurrence risk, Recurrent aspiration, Respiratory tract, Respiratory unit, Severe gastroesophageal, Side effects, Surfactant protein, Treatment Outcome, Vital capacity, Wide spectrum.

Abstract

Interstitial lung disease (ILD) of unknown etiology in immunocompetent patients is rare in children. A national survey was carried out in the United Kingdom and Ireland over a 3‐year period in order to identify prevalence, age distribution, histopathology, natural history of the illness, and response to current treatment. Forty‐six cases were identified, including 29 males and 17 females. Seventy‐six percent presented in the first year of life. Nine (16%) occurred within four families. Conventional treatment with pulsed methylprednisolone, prednisolone, or hydroxychloroquine, singly or in combination, resulted in an excellent response in 65% of cases. Seven children died (15%). The recurrence risk for further children within the same family to develop ILD is estimated to be approximately 10%. The prevalence rate of this condition in the United Kingdom and Ireland during the period of study for children aged 0–16 years is estimated to be 3.6 cases/million. Pediatr Pulmonol. 2002; 34:23–29. © 2002 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-9ZRL6F09-0/fulltext.pdf

DOI: 10.1002/ppul.10125

Affiliations:

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<term>Age Distribution</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Clinical form</term>
<term>Female</term>
<term>Health Surveys</term>
<term>Humans</term>
<term>Idiopathic</term>
<term>Infant</term>
<term>Interstitial pneumonitis</term>
<term>Ireland (epidemiology)</term>
<term>Lung Diseases, Interstitial (epidemiology)</term>
<term>Lung Diseases, Interstitial (physiopathology)</term>
<term>Lung Diseases, Interstitial (therapy)</term>
<term>Male</term>
<term>Prognosis</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>United Kingdom</term>
<term>United Kingdom (epidemiology)</term>
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<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Enquêtes de santé</term>
<term>Femelle</term>
<term>Humains</term>
<term>Irlande (épidémiologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Pneumopathies interstitielles ()</term>
<term>Pneumopathies interstitielles (physiopathologie)</term>
<term>Pneumopathies interstitielles (épidémiologie)</term>
<term>Royaume-Uni (épidémiologie)</term>
<term>Répartition par âge</term>
<term>Résultat thérapeutique</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ireland</term>
<term>Lung Diseases, Interstitial</term>
<term>United Kingdom</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Pneumopathies interstitielles</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Irlande</term>
<term>Pneumopathies interstitielles</term>
<term>Royaume-Uni</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Enfant</term>
<term>Forme clinique</term>
<term>Idiopathique</term>
<term>Pneumopathie interstitielle</term>
<term>Pronostic</term>
<term>Royaume Uni</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Adolescent</term>
<term>Age Distribution</term>
<term>Alveolitis</term>
<term>Biopsy</term>
<term>Bronchoalveolar lavage</term>
<term>Brosing alveolitis</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Clinical practice</term>
<term>Conventional treatment</term>
<term>Desquamative</term>
<term>Dinwiddie</term>
<term>Female</term>
<term>Fibrosing alveolitis</term>
<term>Good outcome</term>
<term>Grant sponsor</term>
<term>Great ormond street hospital</term>
<term>Health Surveys</term>
<term>Histological</term>
<term>Histological change</term>
<term>Humans</term>
<term>Hydroxychloroquine</term>
<term>Idiopathic</term>
<term>Individual data</term>
<term>Infant</term>
<term>Interstitial</term>
<term>Interstitial lung disease</term>
<term>Interstitial pneumonitis</term>
<term>Lung biopsy</term>
<term>Lung disease</term>
<term>Male</term>
<term>National survey</term>
<term>Natural history</term>
<term>Open lung biopsy</term>
<term>Orid desquamation</term>
<term>Other treatments</term>
<term>Oxygen saturation</term>
<term>Partial response</term>
<term>Pediatr</term>
<term>Pediatr pulmonol</term>
<term>Pediatric pulmonology</term>
<term>Pneumonitis</term>
<term>Recurrence risk</term>
<term>Recurrent aspiration</term>
<term>Respiratory tract</term>
<term>Respiratory unit</term>
<term>Severe gastroesophageal</term>
<term>Side effects</term>
<term>Surfactant protein</term>
<term>Treatment Outcome</term>
<term>Vital capacity</term>
<term>Wide spectrum</term>
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<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Enquêtes de santé</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Nourrisson</term>
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<front><div type="abstract" xml:lang="en">Interstitial lung disease (ILD) of unknown etiology in immunocompetent patients is rare in children. A national survey was carried out in the United Kingdom and Ireland over a 3‐year period in order to identify prevalence, age distribution, histopathology, natural history of the illness, and response to current treatment. Forty‐six cases were identified, including 29 males and 17 females. Seventy‐six percent presented in the first year of life. Nine (16%) occurred within four families. Conventional treatment with pulsed methylprednisolone, prednisolone, or hydroxychloroquine, singly or in combination, resulted in an excellent response in 65% of cases. Seven children died (15%). The recurrence risk for further children within the same family to develop ILD is estimated to be approximately 10%. The prevalence rate of this condition in the United Kingdom and Ireland during the period of study for children aged 0–16 years is estimated to be 3.6 cases/million. Pediatr Pulmonol. 2002; 34:23–29. © 2002 Wiley‐Liss, Inc.</div>
</front>
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Idiopathic interstitial pneumonitis in children: A national survey in the United Kingdom and Ireland

Idiopathic interstitial pneumonitis in children: A national survey in the United Kingdom and Ireland

Source :

Descripteurs français

English descriptors

Abstract

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